The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.

Quarraisha Abdool Karim is an epidemiologist in Durban. She talks about the start of the South African AIDS epidemic and the South African AIDS response, health policies and campaigns. She explains why women are more susceptible to HIV than men are.

Fernando Aiuti is an Italian Immunologist who has been working on HIV/AIDS since the early 80's. In this interview he talks about the Italian AIDS situation, sexuality education and the scientific and clinical work in the field.