Dr James Curran, mostly known for his work at the Centers for Disease Control and Prevention (CDC) in the 1980's, pinpoints several key events and persons linked with the very first years of discoveries on HIV and AIDS.

In the last part of the interview with Dr Anthony Fauci he reflects on the global HIV/AIDS situation and response. He also compares AIDS to other diseases such as the Bird Flu, and discusses the specific social and socioeconomic factors of HIV/AIDS.