Staffan Hildebrand looks back on his 25 years of documenting the HIV and AIDS epidemic for the Face of AIDS Film Archive. The film portrays a shift from pessimism towards a growing optimism in the response to HIV and AIDS.

Quarraisha Abdool Karim is an epidemiologist in Durban. She talks about the start of the South African AIDS epidemic and the South African AIDS response, health policies and campaigns. She explains why women are more susceptible to HIV than men are.

Jonathan Mann, was a US medical doctor and influential within the World Health Organization (WHO). Here he talks about the global understanding of the disease between 1981 and 1988.

Nobel Prize Laureate Luc Montagnier answers questions on the origin of HIV, the spreading of the virus, prevention, and the possibility of a vaccine.