Quarraisha Abdool Karim is an epidemiologist in Durban. She talks about the start of the South African AIDS epidemic and the South African AIDS response, health policies and campaigns. She explains why women are more susceptible to HIV than men are.

4th International AIDS Conference in Stockholm in 1988. Australian Judge Michael Kirby estimates the prevalence of HIV/AIDS and talks about the scientific discoveries so far. He reflects on the moral issues connected with AIDS and talks about stigma and civil rights.

Jonathan Mann, was a US medical doctor and influential within the World Health Organization (WHO). Here he talks about the global understanding of the disease between 1981 and 1988.

Nobel Prize Laureate Luc Montagnier answers questions on the origin of HIV, the spreading of the virus, prevention, and the possibility of a vaccine.