4th South African AIDS Conference in Durban. Closing session with a speech by South African Minister of Health, Barbara Hogan, about policies and strategies for human rights and HIV prevention interventions. Discovery Health award to scientist in the HIV field.

XVII International AIDS Conference in Mexico City. Interview with Fatma Hacioglu from Turkey and David Jason Wessenaar from South Africa, two advocates for youth sexual and reproductive rights. They talk about sexuality education in their home countries.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.