This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Dr Robert Gallo is interviewed in the laboratory about the HIV virus and his ongoing work. He also talks with his team and discusses the question of international collaboration with Lars Olof Kallings. He answers questions about HIV and AIDS, drugs and promiscuity.