Mary-Jane Matsolo from the Treatment Action Campaign (TAC) visits the Umbogintwini area outside of Durban and talks about the high prevalence of HIV and the limited access to health care and treatment in the area.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.