Opening ceremony of the Global Village at the XIX International AIDS Conference in Washington D.C. in 2012. The Jamaican musical group The Ashe Company performs an educational musical called Safe Stupid or What. It is about youth, love, sex and HIV.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.