This film is about the global AIDS situation. The film starts in Europe and the United States and ends up in Zimbabwe and Uganda. It tells about the global disparities of drug access, but also about the successful HIV and AIDS responses of Thailand, Cambodia and Uganda.

Quarraisha Abdool Karim is an epidemiologist in Durban. She talks about the start of the South African AIDS epidemic and the South African AIDS response, health policies and campaigns. She explains why women are more susceptible to HIV than men are.