This is the story of four women living with HIV, who are active in the work against HIV/AIDS in Indonesia, Bolivia, Kenya and Sweden. They tell about their lives and their work with health education, advocacy, and support of women and children.

M.D. Mervyn Silverman is one of the pioneers in the HIV/AIDS epidemic. Here he talks about the shifts of topics on the International AIDS Conferences between 1985 and 2008, about the so called San Francisco Model of AIDS care, and about the closing of the Bathhouses.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Last part of the interview with the American AIDS activist and founder of Project Inform, Martin Delaney, in 2006. Here he talks about AIDS activism and the different stages of the antiretroviral drug development from AZT to triple combination treatment.

This documentary focuses on stigma and the situation of people living with HIV in Sweden. The film focuses on the consequences of the ignorance and lack of information on HIV and AIDS. It is a story of three individuals living with HIV.

Lars Olof Kallings talks about the global AIDS situation and what the international community can do. He reflects on the role of men, women and young people in the fight against AIDS, and stresses the importance of activists and voluntary organizations.