XVII International AIDS Conference in Mexico City. Mexican AIDS activist Ricardo Baruch is interviewed about youth AIDS activism and leadership in the HIV/AIDS response, the progresses of Mexican HIV/AIDS policy and the leadership of UNAIDS Director Peter Piot.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.