This film is about women from different parts of the world who are active in the HIV activist movement. They discuss gender inequality and the exposed situation of women and girls and explain the educational and empowering work which they are doing in their communities.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.