This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Interview with George Louis, Professor and Director at the division of Vaccine and Research at the Initiative of Human Virology (IHV) in Baltimore. He talks about the current HIV vaccine trials and reflects on the future.