American actress Sharon Stone talks about her memories of Rock Hudson and her work with amfAR. She reflects on AIDS and stigma, how to reach out to young people, and the importance of communication in order to change the sexual behaviors of young people.

Opening of the Cent Gardes Conference in Annecy in 2002. Speeches by the Director of Fondation Mérieux, Alain Mérieux, and participants from other institutions working on HIV vaccines. The film maker Staffan Hildebrand holds a speech about Face of AIDS.

Joep Lange discusses his views on antiretroviral drugs, both in the developing and the developed world, future improvements of HIV drugs and treatment, and a possible vaccine.

Geoffrey Schild, Virologist and Director of the National Institute for Biological Standards and Control (NIBSC), talks about the Swedish contributions to AIDS research and collaboration with funding agencies such as Nutek, and reflects on HIV vaccines.

Dr George Galasso is working on HIV vaccines at NIAID. Here he talks about the scientific challenges of HIV/AIDS and the chances of developing a vaccine. He believes that one of the main focuses in HIV/AIDS research still is to find treatment for opportunistic infections.