The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.

Helene Gayle is an AIDS expert who has been working in many different initiatives in the US, among them the Centers for Disease Control (CDC). She also works in President Obama's advisory group on HIV/AIDS. Here she talks about understanding and changing behaviors.