Staffan Hildebrand returns to Australia, where he started his project of documenting the AIDS epidemic in 1988, and to Cambodia where he first arrived in 1998. He interviews some of the scientists and activists who he met back then and displays some footage from the archive.

Interview with Hon. Dr Neal Blewett, Australian Minister for Health 1983-90, on the Australian HIV response.

Interview with David Cooper, Director of The Kirby Institute at the University of New South Wales.

Interview with Don Baxter, an HIV activist for more then 30 years, and cutaways in his home.

David Penington, Australian doctor, academic, Vice-Chancellor and director, discusses strategies in the Australian HIV response.

An interview with Brendan Crabb, President of Burnet Institute, on funding, the role of philanthropy, science today and in the future.

Sharon Lewin, Australian Infectious Disease physician and researcher, talks about the advances in HIV research and challenges for the future.

Staffan Hildebrand looks back on his 25 years of documenting the HIV and AIDS epidemic for the Face of AIDS Film Archive. The film portrays a shift from pessimism towards a growing optimism in the response to HIV and AIDS.