This film is about women from different parts of the world who are active in the HIV activist movement. They discuss gender inequality and the exposed situation of women and girls and explain the educational and empowering work which they are doing in their communities.

Jamaican physician Dorothy Blake explains how other sexually transmitted diseases can make HIV easier to catch. She also talks about three main aspects of HIV prevention, which for instance includes a safe sex approach rather than a behavior modification approach.

Jonathan Mann, was a US medical doctor and influential within the World Health Organization (WHO). Here he talks about the global understanding of the disease between 1981 and 1988.

Dr Samuel Okware, the director of National Ugandan AIDS Commission, talks about AIDS in Africa, global impact and commitment.