Interviews with young HIV and AIDS activists from Cambodia, Mexico, Sweden, South Africa, and the United States, on youth, HIV and AIDS.

Staffan Hildebrand looks back on his 25 years of documenting the HIV and AIDS epidemic for the Face of AIDS Film Archive. The film portrays a shift from pessimism towards a growing optimism in the response to HIV and AIDS.

4th South African AIDS Conference in Durban. Closing session with a speech by South African Minister of Health, Barbara Hogan, about policies and strategies for human rights and HIV prevention interventions. Discovery Health award to scientist in the HIV field.

4th South African AIDS Conference in Durban. Interview with Bright Pirri, Communications Coordinator at Southern African AIDS Trust (SAT). He talks about the role of the conference in mobilizing the community response to HIV and AIDS in southern Africa.

Cutaways from the 4th South African AIDS Conference in Durban in 2009, with a session on male circumcision and a demonstration for human rights and access to antiretroviral treatment.

Panel session at the 4th South African AIDS Conference, discussing youth activism, child advocacy and women's rights in relation to HIV and AIDS. Among the speakers are Archbishop Desmond Tutu and Deputy President of South Africa Baleka Mbeti.

This film is about women from different parts of the world who are active in the HIV activist movement. They discuss gender inequality and the exposed situation of women and girls and explain the educational and empowering work which they are doing in their communities.