This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

In the last part of the interview with Dr Anthony Fauci he reflects on the global HIV/AIDS situation and response. He also compares AIDS to other diseases such as the Bird Flu, and discusses the specific social and socioeconomic factors of HIV/AIDS.

This is the third part of the interview with Dr Anthony Fauci. Here he talks about the American AIDS movement in the early 80's with activists such as the writer Larry Kramer in the frontline, and the time when he invited the leading activists up to his office.