This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Joep Lange discusses his views on antiretroviral drugs, both in the developing and the developed world, future improvements of HIV drugs and treatment, and a possible vaccine.

José Esparza is a scientist who has been working many years at WHO and within UNAIDS. He has been known for his work on HIV vaccines. Here he talks about vaccine trials and the future development of vaccines for developing and developed countries.