The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.

Robin Weiss, a British Molecular Biologist and Professor of Viral Oncology at University College London, talks about the scientific contribution of small countries like Sweden, interdisciplinary collaborations in HIV research and HIV vaccines.