This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Professor Sikhamani Rajasekaran, Supervisor of the Tambaram Hospital in Chennai, talks about the HIV/AIDS outbreak in India, the prevalence of TB co-infection and the services at Tambaram Hospital as well as the need for second-line antiretroviral treatment options.

Joep Lange discusses his views on antiretroviral drugs, both in the developing and the developed world, future improvements of HIV drugs and treatment, and a possible vaccine.