This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Dr Luc Montagnier and Dr Lars Olof Kallings in Montagnier’s office and laboratory at the Pasteur Institute in Paris. They talk about the HIV virus and the difficulties and possibilities of finding effective antiretroviral drug combinatoions in the future.