This film is about the global AIDS situation. The film starts in Europe and the United States and ends up in Zimbabwe and Uganda. It tells about the global disparities of drug access, but also about the successful HIV and AIDS responses of Thailand, Cambodia and Uganda.

Joep Lange discusses his views on antiretroviral drugs, both in the developing and the developed world, future improvements of HIV drugs and treatment, and a possible vaccine.

Dr George Galasso is working on HIV vaccines at NIAID. Here he talks about the scientific challenges of HIV/AIDS and the chances of developing a vaccine. He believes that one of the main focuses in HIV/AIDS research still is to find treatment for opportunistic infections.