This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

David Klatzmann is a french immunologist who has been working in an AIDS group in France since 1981. He talks about the discoveries that CD4-antigens function as receptors for the HIV virus and explains the structure of this relationship in detail.

Praphan Phanupak, co-founder of the Thai Red Cross AIDS Research Center (TRC-ARC) and Professor at the Chulalongkorn University Hospital, tells about his encounter with the first AIDS patient in Thailand, about the health resources in Thailand and about stigma.