Staffan Hildebrand returns to Australia, where he started his project of documenting the AIDS epidemic in 1988, and to Cambodia where he first arrived in 1998. He interviews some of the scientists and activists who he met back then and displays some footage from the archive.

Interviews with young HIV and AIDS activists from Cambodia, Mexico, Sweden, South Africa, and the United States, on youth, HIV and AIDS.

Staffan Hildebrand looks back on his 25 years of documenting the HIV and AIDS epidemic for the Face of AIDS Film Archive. The film portrays a shift from pessimism towards a growing optimism in the response to HIV and AIDS.

Follow-up interview with Oum Sopheap who is the director of KHANA. He watches a clip from 1998 and talks about the situation back then and what has happened since 1998 in Cambodia.

This is the story of four women living with HIV, who are active in the work against HIV/AIDS in Indonesia, Bolivia, Kenya and Sweden. They tell about their lives and their work with health education, advocacy, and support of women and children.

XVII International AIDS Conference in Mexico City. Interview with Carissa Etienne, Assistant Director-General at WHO and Jim Yong Kim, Professor and since 2012 President of The World Bank. They talk about the leadership of Jonathan Mann and Peter Piot.

XVII International AIDS Conference in Mexico City. Cutaways of conference delegates.

XVII International AIDS Conference in Mexico City. Yacid Estrada Santiago from Colombia Red Cross reflects on the future face of the HIV/AIDS epidemic and the future of stigma against people living with HIV/AIDS.

XVII International AIDS Conference in Mexico City. Interview with Jimmy Kolker, Chief of the HIV/AIDS section at the New York headquarter of UNICEF. He talks about the initiation of the Pepfar program, which he was part of, and how to target youths and children.

XVII International AIDS Conference in Mexico City. Interview with MD Mubashar Sheikh, Executive Director of Global Health Workforce Alliance at WHO. He talks about international cooperation and leadership in HIV/AIDS policy and the HIVAIDS situation in Iran and Pakistan.

XVII International AIDS Conference in Mexico City. Panel session on global health policy with the President of The World Bank, Jim Yong Kim, and Catherine Hankins from University of Amsterdam, among others.

This is a short film about the global HIV and AIDS response lead by the young generation. Youths and representatives of community networks and health care centers in Cambodia, United States, Mexico, Botswana, Russia and India talk about HIV awareness and prevention.