This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

In the last part of the interview with Dr Anthony Fauci he reflects on the global HIV/AIDS situation and response. He also compares AIDS to other diseases such as the Bird Flu, and discusses the specific social and socioeconomic factors of HIV/AIDS.

Praphan Phanupak, co-founder of the Thai Red Cross AIDS Research Center (TRC-ARC) and Professor at the Chulalongkorn University Hospital, tells about his encounter with the first AIDS patient in Thailand, about the health resources in Thailand and about stigma.