XVIII International AIDS Conference in Vienna in 2010. Peter Piot, Seth Berkley, José Esparza, Helene Gayle and Alan Bernstein talk about HIV vaccine development strategies.

XVII International AIDS Conference in Mexico City. American HIV/AIDS pioneer Dr Anthony Fauci from the National Institute of Allergy and Infectious Diseases (NIAID) talks about the disappointments of the latest HIV vaccine trials, and the leadership of Peter Piot.

XVII International AIDS Confrerence in Mexico City. The UNAIDS Executive Director, Peter Piot, is leading the seminar "Taking the Long-Term View AIDS 2031". He talks about the future leadership and international collaboration in HIV and AIDS research.

XVII International AIDS Conference in Mexico City. Ending of a panel session on the vaccine trials of the International AIDS Vaccine Initiative (IAVI). Seth Berkley, Alan Bernstein and Omu Anzala respond to questions from the audience.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.