Dr James Curran, mostly known for his work at the Centers for Disease Control and Prevention (CDC) in the 1980's, pinpoints several key events and persons linked with the very first years of discoveries on HIV and AIDS.

Ronald D. Stall, professor focusing his work on AIDS and behavioral research, talks about the behavior changes within the homosexual community in the Castro District which had one of the highest HIV prevalences in North America in 1988.

Two interviews with Dr Mervyn Silverman, from 1988 and 2008. He explains the San Francisco model, how it began and what others can learn from it.

Two interviews with Martin Delaney from 1994 and 1998, where he explains the work and aims of Project Informs. Shots from the Project Inform Hotline.

The Journalist David Perlman from San Francisco Chronicle was the first American journalist to report on AIDS in June 1981. He tells the story of his first article on AIDS, and how reporting on the epidemic affected him.

Nicole, a teenage girl living in San Francisco, is interviewed about the voluntary work she has done in the Glide Memorial Church in San Francisco.

Diane Johns is a nurse at San Francisco General Hospital. She shares her thoughts on terminal care, patient participation, home based care, and homelessness. Diane started to work at San Francisco General Hospital in 1982 and began at the newly opened AIDS ward in 1983.

Bart is working in a hotel for people who are living with HIV/AIDS in San Francisco. He tells about the mission of the program and the services provided. The hotel is for people who for any reason need housing, care and support.

Dr Mervyn Silverman, HIV activist Scott Millar and Gert McMullin talks about the history of the AIDS Memorial Quilt, and its significance.

Interviews with young HIV and AIDS activists from Cambodia, Mexico, Sweden, South Africa, and the United States, on youth, HIV and AIDS.

XIX International AIDS Conference in Washington D.C. Congresswoman Barbara Lee comments on the United States travel restrictions against people living with HIV that was resolved in 2012 after 22 years. She also reflects on the possibilities of ending AIDS.

XIX International AIDS Conference. Interview with Michel Kazatzhkine who is the United Nations HIV Special Representative for Eastern Europe and Central Asia. Here he talks about harm reduction policies and the situation for people who are using drugs.