This is the story about Steve Sjöquist - writer, HIV activist and deacon at Karolinska Universitetssjukhuset in Stockholm. Steve was diagnosed with HIV in 1987 and he was one of the first Swedish AIDS patients to get the new antiretroviral therapy in 1996. It saved his life.

American actress Sharon Stone talks about her memories of Rock Hudson and her work with amfAR. She reflects on AIDS and stigma, how to reach out to young people, and the importance of communication in order to change the sexual behaviors of young people.

M.D. Mervyn Silverman is one of the pioneers in the HIV/AIDS epidemic. Here he talks about the shifts of topics on the International AIDS Conferences between 1985 and 2008, about the so called San Francisco Model of AIDS care, and about the closing of the Bathhouses.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Quarraisha Abdool Karim is an epidemiologist in Durban. She talks about the start of the South African AIDS epidemic and the South African AIDS response, health policies and campaigns. She explains why women are more susceptible to HIV than men are.