Two interviews with Dr Mervyn Silverman, from 1988 and 2008. He explains the San Francisco model, how it began and what others can learn from it.

Follow-up interview with Oum Sopheap who is the director of KHANA. He watches a clip from 1998 and talks about the situation back then and what has happened since 1998 in Cambodia.

XVII International AIDS Conference in Mexico City. Swedish Dr Lars Olof Kallings who founded the International AIDS Society (IAS) in 1988 and who is now the United Nations Special Envoy for AIDS in Eastern Europe, reflects on the history of the AIDS movement.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.