XIX International AIDS Conference. Panel discussion on youth HIV/AIDS activism focusing on stigma and discrimination, internet and social media in the HIV/AIDS response and how to influence political leaders and older generations to take action.

XVII International AIDS Conference in Mexico City. Closing session with speeches by the Co-chairs Pedro Cahn and Luiz Enrique Soto-Ramírez., as well as the Mayor of Mexico City and the Co-Chairs of the next International AIDS Conference in Vienna in, 2010.

M.D. Mervyn Silverman is one of the pioneers in the HIV/AIDS epidemic. Here he talks about the shifts of topics on the International AIDS Conferences between 1985 and 2008, about the so called San Francisco Model of AIDS care, and about the closing of the Bathhouses.

Hector is a gay activist involved in the prevention work towards young LGBT persons in the Zona Rosa district in Mexico City. He talks about gender roles and gay rights in Mexico and about a comic book which they hand out to young men in this square.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.