Interviews with young HIV and AIDS activists from Cambodia, Mexico, Sweden, South Africa, and the United States, on youth, HIV and AIDS.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Young AIDS activist Ricardo Baruch talks about the international collaboration of youth activists and the AIDS situation in Mexico for LBGT persons and women in rural areas and developing countries. He also reflects on the International AIDS Conference.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.