Two interviews with Dr Mervyn Silverman, from 1988 and 2008. He explains the San Francisco model, how it began and what others can learn from it.

XIX International AIDS Conference. Interview with Michel Kazatzhkine who is the United Nations HIV Special Representative for Eastern Europe and Central Asia. Here he talks about harm reduction policies and the situation for people who are using drugs.

Closing session of the XIX International AIDS Conference with speakers such as Bill Clinton, the two co-chairs of the conference Elly Katabira and Diane Havlir, US politician Nancy Pelosi, Françoise Barré-Sinoussi, and many activists and community leaders.

XIX International AIDS Conference. Interview with Chewe Luo, Senior Adviser on HIV/AIDS at UNICEF in New York. She talks about working with HIV prevention and supporting women's health and the rights of women living with HIV as a first step in ending AIDS.

XVII International AIDS Conference in Mexico City. Interviews with Jasmine Burnett from the Black AIDS Institute in the United States, Yvette Fleming from Stop AIDS Now in the Netherlands and David Lush from Positive Vibes in Namibia, among others.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.