XIX International AIDS Conference. Paul Nsubuga Semugoma from the Global Forum on MSM and HIV, talks about the situation of men who have sex with men in Uganda and how stigma and discrimination interferes with the work to prevent HIV and end AIDS.

XVII International AIDS Conference in Mexico City. Interviews with Jasmine Burnett from the Black AIDS Institute in the United States, Yvette Fleming from Stop AIDS Now in the Netherlands and David Lush from Positive Vibes in Namibia, among others.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.