This film is about the global AIDS situation. The film starts in Europe and the United States and ends up in Zimbabwe and Uganda. It tells about the global disparities of drug access, but also about the successful HIV and AIDS responses of Thailand, Cambodia and Uganda.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.

Alec works as a manager in a harm reduction program and does street outreach work among young drug users in the streets of Moscow.

Flossie Wong-Staal is an American Molecular Biologist who has been influencial in the HIV/AIDS research since the start of the US AIDS epidemic. She is known as the first scientist to clone HIV. In this interview she talks about the work on HIV gene therapy.

Joep Lange discusses his views on antiretroviral drugs, both in the developing and the developed world, future improvements of HIV drugs and treatment, and a possible vaccine.

Joep Lange discusses his views on antiretroviral drugs, both in the developing and the developed world, future improvements of HIV drugs and treatment, and a possible vaccine.

MD Eric Sandström talks about the Swedish health care situation for people living with HIV and his personal experiences of working with HIV patients. He also talks about the advantages of early ARV treatment, and the organized HIV testing strategies in Sweden.

Fernando Aiuti is an Italian Immunologist who has been working on HIV/AIDS since the early 80's. In this interview he talks about the Italian AIDS situation, sexuality education and the scientific and clinical work in the field.

Interview with Agneta Dreber from Folkhälsomyndigheten (National Institute of Public Health) in Sweden. She talks about the Swedish HIV/AIDS situation, about sexuality education in schools and HIV/AIDS education in workplaces.

José Esparza is a scientist who has been working many years at WHO and within UNAIDS. He has been known for his work on HIV vaccines. Here he talks about vaccine trials and the future development of vaccines for developing and developed countries.

Praphan Phanupak is Professor in Immunology and the Director of the Thai Red Cross AIDS Research Centre (TRC-ARC). He talks about the incidence and prevalence of HIV infection in different parts of Thailand and about human experiments on Thai drug users.

Jamaican physician Dorothy Blake explains how other sexually transmitted diseases can make HIV easier to catch. She also talks about three main aspects of HIV prevention, which for instance includes a safe sex approach rather than a behavior modification approach.