Staffan Hildebrand returns to Australia, where he started his project of documenting the AIDS epidemic in 1988, and to Cambodia where he first arrived in 1998. He interviews some of the scientists and activists who he met back then and displays some footage from the archive.

Staffan Hildebrand looks back on his 25 years of documenting the HIV and AIDS epidemic for the Face of AIDS Film Archive. The film portrays a shift from pessimism towards a growing optimism in the response to HIV and AIDS.

Follow-up interview with Oum Sopheap who is the director of KHANA. He watches a clip from 1998 and talks about the situation back then and what has happened since 1998 in Cambodia.

This is the story of four women living with HIV, who are active in the work against HIV/AIDS in Indonesia, Bolivia, Kenya and Sweden. They tell about their lives and their work with health education, advocacy, and support of women and children.

Professor Sikhamani Rajasekaran, Supervisor of the Tambaram Hospital in Chennai, talks about the HIV/AIDS outbreak in India, the prevalence of TB co-infection and the services at Tambaram Hospital as well as the need for second-line antiretroviral treatment options.

This film is about the global AIDS situation. The film starts in Europe and the United States and ends up in Zimbabwe and Uganda. It tells about the global disparities of drug access, but also about the successful HIV and AIDS responses of Thailand, Cambodia and Uganda.