This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Second and last part of the interview with UNAIDS coordinator Tony Lisle. Here he talks about the UNAIDS leadership and community-based work targeting male sex workers. He also explains why it is particularly difficult to reach out to male sex workers.

Interview with Moises who has been working with HIV prevention since 2000. Here he tells about the Mexican NGO AcciónH and the condom promotion they do in gay bars in Mexico City.

Young AIDS activist Ricardo Baruch talks about the international collaboration of youth activists and the AIDS situation in Mexico for LBGT persons and women in rural areas and developing countries. He also reflects on the International AIDS Conference.