The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.

Students are interviewed on the street in Washington DC, about HIV/AIDS and prevention.

Interview with Agneta Dreber from Folkhälsomyndigheten (National Institute of Public Health) in Sweden. She talks about the Swedish HIV/AIDS situation, about sexuality education in schools and HIV/AIDS education in workplaces.

Jamaican physician Dorothy Blake explains how other sexually transmitted diseases can make HIV easier to catch. She also talks about three main aspects of HIV prevention, which for instance includes a safe sex approach rather than a behavior modification approach.