This film is about the global AIDS situation. The film starts in Europe and the United States and ends up in Zimbabwe and Uganda. It tells about the global disparities of drug access, but also about the successful HIV and AIDS responses of Thailand, Cambodia and Uganda.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.

Alec works as a manager in a harm reduction program and does street outreach work among young drug users in the streets of Moscow.

Dr Ingrid van Beek from the Sydney Medically Supervised Injecting Centre (MSIC), a program offering HIV testing, counseling, needle-exchange and methadone programs. She talks about the challenges and successes of the Australian AIDS response.

This production from 1990 debates the worldwide HIV/AIDS situation for women and children. The stigmatization of female sexuality is considered the primary reason of women's particularly exposed situation when it comes to sexually transmitted diseases.