Two interviews with Dr Mervyn Silverman, from 1988 and 2008. He explains the San Francisco model, how it began and what others can learn from it.

Mary-Jane Matsolo from the Treatment Action Campaign (TAC) visits the Umbogintwini area outside of Durban and talks about the high prevalence of HIV and the limited access to health care and treatment in the area.

Follow-up interview with Oum Sopheap who is the director of KHANA. He watches a clip from 1998 and talks about the situation back then and what has happened since 1998 in Cambodia.

4th South African AIDS Conference in Durban. Closing session with a speech by South African Minister of Health, Barbara Hogan, about policies and strategies for human rights and HIV prevention interventions. Discovery Health award to scientist in the HIV field.

Opening session of the 4th South African AIDS Conference in Durban in 2009. Professor Linda Gail Bekker from University of Cape Town talks about the HIV/AIDS situation in South Africa. The film also includes music performances and location shots.