This film is about the global AIDS situation. The film starts in Europe and the United States and ends up in Zimbabwe and Uganda. It tells about the global disparities of drug access, but also about the successful HIV and AIDS responses of Thailand, Cambodia and Uganda.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.

Diane Johns is a nurse at San Francisco General Hospital. She shares her thoughts on terminal care, patient participation, home based care, homelessness, sex education and morality, stigma and other questions related to HIV and AIDS.

Dale Rogers is a lab assistant at San Francisco General Hospital. Here he talks about the relationship between health personnel and AIDS patients and how working with young AIDS patients affects his life. He also talks about stigma among health personnel.