American actress Sharon Stone talks about her memories of Rock Hudson and her work with amfAR. She reflects on AIDS and stigma, how to reach out to young people, and the importance of communication in order to change the sexual behaviors of young people.

XVII International AIDS Conference in Mexico City. Interview with Dr Mervyn Silverman from San Francisco, who has been active in the AIDS movement since the early 80's. Here he reflects on the leadership of UNAIDS Director Peter Piot.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.