Dr James Curran, mostly known for his work at the Centers for Disease Control and Prevention (CDC) in the 1980's, pinpoints several key events and persons linked with the very first years of discoveries on HIV and AIDS.

Two interviews with Martin Delaney from 1994 and 1998, where he explains the work and aims of Project Informs. Shots from the Project Inform Hotline.

The Journalist David Perlman from San Francisco Chronicle was the first American journalist to report on AIDS in June 1981. He tells the story of his first article on AIDS, and how reporting on the epidemic affected him.

Diane Johns is a nurse at San Francisco General Hospital. She shares her thoughts on terminal care, patient participation, home based care, and homelessness. Diane started to work at San Francisco General Hospital in 1982 and began at the newly opened AIDS ward in 1983.

Interview with Hon. Dr Neal Blewett, Australian Minister for Health 1983-90, on the Australian HIV response.

Interview with David Cooper, Director of The Kirby Institute at the University of New South Wales.

Interview with Don Baxter, an HIV activist for more then 30 years, and cutaways in his home.

David Penington, Australian doctor, academic, Vice-Chancellor and director, discusses strategies in the Australian HIV response.

An interview with Brendan Crabb, President of Burnet Institute, on funding, the role of philanthropy, science today and in the future.

Sharon Lewin, Australian Infectious Disease physician and researcher, talks about the advances in HIV research and challenges for the future.

Steve Sjöquist comments on the play "Ömheten" at Stadsteatern in Stockholm.

XIX International AIDS Conference in Washington D.C. Congresswoman Barbara Lee comments on the United States travel restrictions against people living with HIV that was resolved in 2012 after 22 years. She also reflects on the possibilities of ending AIDS.