Opening session of the 4th South African AIDS Conference in Durban in 2009. Professor Linda Gail Bekker from University of Cape Town talks about the HIV/AIDS situation in South Africa. The film also includes music performances and location shots.

XVII International AIDS Conference in Mexico City. Interview with Paul Bekkers who is the AIDS Ambassador for the Netherlands. He talks about national leadership in the global response to HIV and AIDS, about youth and sexuality education.

Sten Vermund from University of Alabama reflects on the history of the global AIDS epidemic and his involvement in the field as a young scientist in the 80's. He discusses the social and economic factors of HIV/AIDS, such as stigma, poverty and the drug industry.