French virologist and Nobel Prize winner Luc Montagnier reflects on the discovery of HIV, discusses disappointments and lessons learned along the way and the possibility of a vaccine, and gives advice for future AIDS researchers.

Sten Vermund from University of Alabama reflects on the history of the global AIDS epidemic and his involvement in the field as a young scientist in the 80's. He discusses the social and economic factors of HIV/AIDS, such as stigma, poverty and the drug industry.

Annual HIV research conference arranged by IHV. Dr Robert Gallo holds a lecture on the history of medical research on human retroviruses. He also talks about the early discoveries of t-cell leukemia in Japanese patients, which led to the discovery of HTLV-1.

Interview with George Louis, Professor and Director at the division of Vaccine and Research at the Initiative of Human Virology (IHV) in Baltimore. He talks about the current HIV vaccine trials and reflects on the future.

Interview with Pathologist Christian Isichei, founder of the Faith Alive Hospital in Jos in Nigeria. He talks about the drug industry and access to ARV treatment in Africa and his experiences from the annual conference at the Institute of Human Virology (IHV) in Baltimore.

Steve Gold, professor at John Hopkins University in the Department of Biological Chemistry, talks about the paradigms of the HIV/AIDS research fields.