Interview with Pathologist Christian Isichei, founder of the Faith Alive Hospital in Jos in Nigeria. He talks about the drug industry and access to ARV treatment in Africa and his experiences from the annual conference at the Institute of Human Virology (IHV) in Baltimore.

Steve Gold, professor at John Hopkins University in the Department of Biological Chemistry, talks about the paradigms of the HIV/AIDS research fields.

Gary Nabel, from the Vaccine Research Center (VRC) talks about engaging the scientific community and health personnel in HIV research and about the importance of international conferences to create these kinds of collaborations.

Marc Girard who is the general director of the Mérieux Foundation, talks about Cent Gardes and the collaboration between France and the USA, mainly represented by the Pasteur Institute and NIH, and about why HIV is such a complicated virus to find a vaccine for.

Dr Robert C Gallo talks about the importance of yearly AIDS congresses. He also talks about the scientific community before and during the AIDS epidemic, and puts the disease outbreak into a sociological context.

David Klatzmann is a french immunologist who has been working in an AIDS group in France since 1981. He talks about the discoveries that CD4-antigens function as receptors for the HIV virus and explains the structure of this relationship in detail.

Mary Marovich, medical scientist at The Walter Reed Army Medical Center in Washington, talks about the difficulties and possibilities of eventually finding an AIDS vaccine solution.

Luc Montagnier talks about the complex virology of HIV which makes the AIDS vaccine development so difficult. He also talks about the economic and cultural advantages of using traditional medicine as a part of the ARV therapy in developing countries.

Opening of the Cent Gardes Conference in Annecy in 2002. Speeches by the Director of Fondation Mérieux, Alain Mérieux, and participants from other institutions working on HIV vaccines. The film maker Staffan Hildebrand holds a speech about Face of AIDS.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.

Quarraisha Abdool Karim is an epidemiologist in Durban. She talks about the start of the South African AIDS epidemic and the South African AIDS response, health policies and campaigns. She explains why women are more susceptible to HIV than men are.

Anthony Fauci is interviewed about the progression from HIV to AIDS. He talks about HIV long-term survivors and different aspects of non-progression to AIDS. He also reflects on the future for antiretroviral drugs and HIV vaccines.