Dr James Curran, mostly known for his work at the Centers for Disease Control and Prevention (CDC) in the 1980's, pinpoints several key events and persons linked with the very first years of discoveries on HIV and AIDS.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

This is the third part of the interview with Dr Anthony Fauci. Here he talks about the American AIDS movement in the early 80's with activists such as the writer Larry Kramer in the frontline, and the time when he invited the leading activists up to his office.

French virologist and Nobel Prize winner Luc Montagnier reflects on the discovery of HIV, discusses disappointments and lessons learned along the way and the possibility of a vaccine, and gives advice for future AIDS researchers.