This film is about the global AIDS situation. The film starts in Europe and the United States and ends up in Zimbabwe and Uganda. It tells about the global disparities of drug access, but also about the successful HIV and AIDS responses of Thailand, Cambodia and Uganda.

Alec works as a manager in a harm reduction program and does street outreach work among young drug users in the streets of Moscow.

Helen Jackson from Southern Africa HIV and AIDS Information Dissemination Service (SAfAIDS) talks about short and long term impact of HIV/AIDS in Zimbabwe.

Dr Ingrid van Beek from the Sydney Medically Supervised Injecting Centre (MSIC), a program offering HIV testing, counseling, needle-exchange and methadone programs. She talks about the challenges and successes of the Australian AIDS response.

Students are interviewed on the street in Washington DC, about HIV/AIDS and prevention.

Anthony Fauci is interviewed about the progression from HIV to AIDS. He talks about HIV long-term survivors and different aspects of non-progression to AIDS. He also reflects on the future for antiretroviral drugs and HIV vaccines.

Flossie Wong-Staal is an American Molecular Biologist who has been influencial in the HIV/AIDS research since the start of the US AIDS epidemic. She is known as the first scientist to clone HIV. In this interview she talks about the work on HIV gene therapy.

Interview with Agneta Dreber from Folkhälsomyndigheten (National Institute of Public Health) in Sweden. She talks about the Swedish HIV/AIDS situation, about sexuality education in schools and HIV/AIDS education in workplaces.

José Esparza is a scientist who has been working many years at WHO and within UNAIDS. He has been known for his work on HIV vaccines. Here he talks about vaccine trials and the future development of vaccines for developing and developed countries.

Praphan Phanupak, co-founder of the Thai Red Cross AIDS Research Center (TRC-ARC) and Professor at the Chulalongkorn University Hospital, tells about his encounter with the first AIDS patient in Thailand, about the health resources in Thailand and about stigma.

Robin Weiss, a British Molecular Biologist and Professor of Viral Oncology at University College London, talks about the scientific contribution of small countries like Sweden, interdisciplinary collaborations in HIV research and HIV vaccines.

Geoffrey Schild, Virologist and Director of the National Institute for Biological Standards and Control (NIBSC), talks about the Swedish contributions to AIDS research and collaboration with funding agencies such as Nutek, and reflects on HIV vaccines.