XVII International AIDS Conference in Mexico City. Dr Daria Hazuda from MSD, who has been involved in antiretroviral drug development during the past 20 years, holds a presentation. She is also interviewed about leadership and the progress of ARV and vaccine development.

This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

XVI International AIDS Conference in Toronto. Panel session on health policy with Swedish AIDS Ambassador Lennart Hjelmåker, UNAIDS Executive Director Peter Piot, Indian Minister of Health Anbunmani Romdass, Sipho Mthathi from TAC and Jeffrey Sturchio from Merck.

French virologist and Nobel Prize winner Luc Montagnier reflects on the discovery of HIV, discusses disappointments and lessons learned along the way and the possibility of a vaccine, and gives advice for future AIDS researchers.

Interview with George Louis, Professor and Director at the division of Vaccine and Research at the Initiative of Human Virology (IHV) in Baltimore. He talks about the current HIV vaccine trials and reflects on the future.

Steve Gold, professor at John Hopkins University in the Department of Biological Chemistry, talks about the paradigms of the HIV/AIDS research fields.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.

Dr Robert Gallo is interviewed in the laboratory about the HIV virus and his ongoing work. He also talks with his team and discusses the question of international collaboration with Lars Olof Kallings. He answers questions about HIV and AIDS, drugs and promiscuity.